abstract：:Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of behavior. ASD is, however, often associated with medical comorbidities and gastrointestinal (GI) dysfunction is among the most common. Studies have demonstrated a corr...

journal_title：Pharmacological research

authors： Israelyan N,Margolis KG

更新日期：2018-06-01 00:00:00

abstract：:Evodiae fructus is a widely used herbal drug in traditional Chinese medicine. Evodia extract was found to inhibit hERG channels. The aim of the current study was to identify hERG inhibitors in Evodia extract and to investigate their potential proarrhythmic effects. Dehydroevodiamine (DHE) and hortiamine were identifie...

journal_title：Pharmacological research

authors： Baburin I,Varkevisser R,Schramm A,Saxena P,Beyl S,Szkokan P,Linder T,Stary-Weinzinger A,van der Heyden MAG,Houtman M,Takanari H,Jonsson M,Beekman JHD,Hamburger M,Vos MA,Hering S

更新日期：2018-05-01 00:00:00

abstract：:Severely obese patients undergoing bariatric surgery (BS) are at increased risk for venous thromboembolism (VTE). How standard low molecular weight heparin (LMWH) regimen should be adapted to provide both sufficient efficacy and safety in this setting is unclear. We aimed to compare the influence of four body size des...

journal_title：Pharmacological research

authors： Gaborit B,Moulin PA,Bege T,Boullu S,Vincentelli C,Emungania O,Morange PE,Berdah S,Salem JE,Dutour A,Frere C

更新日期：2018-05-01 00:00:00

abstract：:The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug development for hypertension, heart failure and ischemic heart disease. Indeed, apelin exerts a positive inotropic effect in humans whilst re...

journal_title：Pharmacological research

authors： Besserer-Offroy É,Bérubé P,Côté J,Murza A,Longpré JM,Dumaine R,Lesur O,Auger-Messier M,Leduc R,Marsault É,Sarret P

更新日期：2018-05-01 00:00:00

abstract：:Contrasting results have been reported on the role of rs628031 and rs683369 polymorphisms of SLC22A1 and rs776746 of CYP3A5 on imatinib treatment response in patients with chronic myeloid leukemia (CML). In the present study, we conducted a systematic review and meta-analysis of published studies to estimate the impac...

journal_title：Pharmacological research

authors： Cargnin S,Ravegnini G,Soverini S,Angelini S,Terrazzino S

更新日期：2018-05-01 00:00:00

abstract：:Hepatitis E virus (HEV) is the most common cause of viral hepatitis worldwide. Genotypes 1 and 2 (GT1 and GT2) are mainly present in developing countries, while GT3 and GT4 are prevalent in developed and high-income countries. In the majority of cases, HEV causes a self-limiting hepatitis. GT3 and GT4 can be responsib...

journal_title：Pharmacological research

authors： De Winter BCM,Hesselink DA,Kamar N

更新日期：2018-04-01 00:00:00

abstract：:Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic accompany with metabolic and endocrine disorders worldwide. Most of DM patients are affected by type 2 diabetes mellitus (T2DM) with insulin resistance and insulin secretion defect. Generally, the strategies to treat T2DM are diet...

journal_title：Pharmacological research

authors： Xu L,Li Y,Dai Y,Peng J

更新日期：2018-04-01 00:00:00

abstract：:The smoothened (SMO) receptor, an essential signal transducer in the Hedgehog pathway, was targeted with antagonists to suppress the tumor. It is interesting that SMO D473H mutation confers resistance on inhibitor LDE-225 rather than LEQ-506. In this paper, the binding modes of them against the wild type and mutant SM...

journal_title：Pharmacological research

authors： Tu J,Li JJ,Song LT,Zhai HL,Wang J,Zhang XY

更新日期：2018-03-01 00:00:00

abstract：:Cancer immunotherapies are dramatically reshaping the clinical management of oncologic patients. For many of these therapies, the guidelines for administration, monitoring, and management of associated toxicities are still being established. This is especially relevant for adoptively transferred, genetically-modified ...

journal_title：Pharmacological research

authors： Ramello MC,Haura EB,Abate-Daga D

更新日期：2018-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is regarded as a progressive and devastating neurodegenerative disorder. In aged individuals, it is the most prevalent cause of dementia and is characterized by gradual loss of cognitive functions. In the last decade, numerous research works were undertaken to investigate the pathogenesis of A...

journal_title：Pharmacological research

authors： Sadhukhan P,Saha S,Dutta S,Mahalanobish S,Sil PC

更新日期：2018-03-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is an endogenously produced signaling molecule synthesized by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST). Given that H2S exerts significant effects on bioenergetics and metabolism, the goal of the current study was to determine th...

journal_title：Pharmacological research

authors： Katsouda A,Szabo C,Papapetropoulos A

更新日期：2018-02-01 00:00:00

abstract：:Quiescent hepatic stellate cell (HSC) activation and subsequent conversion into myofibroblasts is the central event in hepatic fibrosis pathogenesis. Epithelial-mesenchymal transition (EMT), another vital participant in liver fibrosis, has the potential to initiate HSC activation, which promotes abundant myofibroblast...

journal_title：Pharmacological research

authors： Zhao H,Wang Z,Tang F,Zhao Y,Feng D,Li Y,Hu Y,Wang C,Zhou J,Tian X,Yao J

更新日期：2018-02-01 00:00:00

abstract：:Exaggerated Janus kinase-signal transducer and activator of transcription (JAK-STAT) signalling is key to the pathogenesis of pro-inflammatory disorders, such as rheumatoid arthritis and cardiovascular diseases. Mutational activation of JAKs is also responsible for several haematological malignancies, including myelop...

journal_title：Pharmacological research

authors： Speirs C,Williams JJL,Riches K,Salt IP,Palmer TM

更新日期：2018-02-01 00:00:00

abstract：:The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse xenograph models (HL-60, MCF-7, PANC-1 and OVCAR-3). To promote this new family of molecules toward a clinical phase 1 trial, the mechanism of action governing the anticancer properties ...

journal_title：Pharmacological research

authors： Perreault M,Maltais R,Kenmogne LC,Létourneau D,LeHoux JG,Gobeil S,Poirier D

更新日期：2018-02-01 00:00:00

abstract：:Oxylipins (OXLs) are bioactive molecules generated by the oxidation of fatty acids that promote the resolution of acute inflammation and prevent chronic inflammatory processes through molecular mechanisms that are not well known. We have previously reported the anti-inflammatory activity of microalgae-derived OXLs and...

journal_title：Pharmacological research

authors： Ávila-Román J,Talero E,de Los Reyes C,García-Mauriño S,Motilva V

更新日期：2018-02-01 00:00:00

abstract：:Since the regenerative capacity of the adult mammalian heart is limited, cardiac injury leads to the formation of scar tissue and thereby increases the risk of developing compensatory heart failure. Stem cell therapy is a promising therapeutic approach but is facing problems with engraftment and clinical feasibility. ...

journal_title：Pharmacological research

authors： Smits AM,Dronkers E,Goumans MJ

更新日期：2018-01-01 00:00:00

abstract：:Stem cell mediated cardiac repair is an exciting and controversial area of cardiovascular research that holds the potential to produce novel, revolutionary therapies for the treatment of heart disease. Extensive investigation to define cell types contributing to cardiac formation, homeostasis and regeneration has prod...

journal_title：Pharmacological research

authors： Gude NA,Sussman MA

更新日期：2018-01-01 00:00:00

abstract：:Metastatic melanoma has been described as a highly aggressive cancer with low sensibility to chemotherapeutic agents. New types of drug, such as metal-based drugs (ferrocifens) have emerged and could represent an alternative for melanoma treatment since they show interesting anticancer potential. Furthermore, molecula...

journal_title：Pharmacological research

authors： Resnier P,Galopin N,Sibiril Y,Clavreul A,Cayon J,Briganti A,Legras P,Vessières A,Montier T,Jaouen G,Benoit JP,Passirani C

更新日期：2017-12-01 00:00:00

abstract：:Biosimilars started receiving the marketing authorization by European Medicine Agency since 2006. The development of biosimilars follows a well-defined step-wise approach, the so-called comparability exercise, which aims to compare non-clinical (mainly quality features and biological activity) and clinical (efficacy a...

journal_title：Pharmacological research

authors： Scavone C,Rafaniello C,Berrino L,Rossi F,Capuano A

更新日期：2017-12-01 00:00:00

abstract：:Melanoma is a highly invasive and metastatic cancer with high mortality rates and chemoresistance. Around 50% of melanomas are driven by activating mutations in BRAF that has led to the development of potent anti-BRAF inhibitors. However resistance to anti-BRAF therapy usually develops within a few months and conseque...

journal_title：Pharmacological research

authors： Oliveira ÉA,Lima DS,Cardozo LE,Souza GF,de Souza N,Alves-Fernandes DK,Faião-Flores F,Quincoces JAP,Barros SBM,Nakaya HI,Monteiro G,Maria-Engler SS

更新日期：2017-11-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a severe muscle disease of known etiology without effective, or generally applicable therapy. Mitochondria are affected by the disease in animal models but whether mitochondrial dysfunction is part of the pathogenesis in patients remains unclear. We show that primary cultures obtai...

journal_title：Pharmacological research

authors： Schiavone M,Zulian A,Menazza S,Petronilli V,Argenton F,Merlini L,Sabatelli P,Bernardi P

更新日期：2017-11-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are among the main causes of death globally and in this context hypertension represents one of the key risk factors for developing a CVD. It is well established that the peripheral renin-angiotensin system (RAS) plays an important role in regulating blood pressure (BP). All components of ...

journal_title：Pharmacological research

authors： Huber G,Schuster F,Raasch W

更新日期：2017-11-01 00:00:00

abstract：:Breast cancer (BC) is the most common cancer in women, and the second most frequent cause of cancer-related deaths in women worldwide. It is a heterogeneous disease composed of multiple subtypes with distinct morphologies and clinical implications. Quantitative systems pharmacology (QSP) is an emerging discipline brid...

journal_title：Pharmacological research

authors： Fleisher B,Brown AN,Ait-Oudhia S

更新日期：2017-10-01 00:00:00

abstract：:Erectile function is a widely accepted indicator of systemic endothelial activity since from a clinical standpoint erectile dysfunction (ED) often precedes cardiovascular events. Recently it has been described a potential role for β3 adrenoceptor in cardiovascular diseases emphasizing a possible development of new dru...

journal_title：Pharmacological research

authors： Mitidieri E,Tramontano T,Gurgone D,Imbimbo C,Mirone V,Fusco F,Cirino G,d'Emmanuele di Villa Bianca R,Sorrentino R

更新日期：2017-10-01 00:00:00

abstract：:Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent...

journal_title：Pharmacological research

authors： Zhu R,Liu H,Liu C,Wang L,Ma R,Chen B,Li L,Niu J,Fu M,Zhang D,Gao S

更新日期：2017-08-01 00:00:00

abstract：:In the last few years, exciting properties have emerged regarding the activation, signaling, mechanisms of action, and therapeutic targeting of the two types of neurotrophin receptors: the p75NTR with its intracellular and extracellular peptides, the Trks, their precursors and their complexes. This review summarizes t...

journal_title：Pharmacological research

authors： Meldolesi J

更新日期：2017-07-01 00:00:00

abstract：:Iron is an essential element for virtually all organisms. It facilitates cell proliferation and growth but also contributes to major hallmarks of cancer such as tumor initiation, growth, and metastasis. Often, iron handling of tumor cells is disturbed, with altered iron acquisition, efflux, and storage. Targeting pert...

journal_title：Pharmacological research

authors： Jung M,Mertens C,Bauer R,Rehwald C,Brüne B

更新日期：2017-06-01 00:00:00

abstract：:Aging has a remarkable effect on cardiovascular homeostasis and it is known as the major non-modifiable risk factor in the development of hypertension. Medications targeting sympathetic nerve system and/or renin-angiotensin-aldosterone system are widely accepted as a powerful therapeutic strategy to improve hypertensi...

journal_title：Pharmacological research

authors： Sunggip C,Nishimura A,Shimoda K,Numaga-Tomita T,Tsuda M,Nishida M

更新日期：2017-06-01 00:00:00

abstract：:Extensive studies have reported the significant roles of numerous cellular features and processes in properly maintaining neuronal morphology and function throughout the lifespan of an animal. Any alterations in their homeostasis appear to be strongly associated with neuronal aging and the pathogenesis of various neur...

journal_title：Pharmacological research

authors： Kwon MJ,Kim JH,Kim T,Lee SB

更新日期：2017-05-01 00:00:00

abstract：:Epidemiological, clinical and animal studies revealed that sex differences exist in the manifestation and outcome of cardiovascular disease (CVD). The underlying molecular mechanisms implicated in these sex differences are not fully understood. The reasons for sex differences in CVD are definitely multifactorial, but ...

journal_title：Pharmacological research

authors： Dworatzek E,Mahmoodzadeh S

更新日期：2017-05-01 00:00:00

abstract：:Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subseque...

journal_title：Pharmacological research

authors： Ganjali S,Blesso CN,Banach M,Pirro M,Majeed M,Sahebkar A

更新日期：2017-05-01 00:00:00

abstract：:Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels sugge...

journal_title：Pharmacological research

authors： Tu Y,Johnstone CN,Stewart AG

更新日期：2017-05-01 00:00:00

abstract：:Endothelial dysfunction (ED), an established response to cardiovascular risk factors, is characterized by increased levels of soluble molecules secreted by endothelial cells (EC). Evidence suggest that ED is an independent predictor of cardiac events and that it is associated with a deficiency in production or bioavai...

journal_title：Pharmacological research

authors： Charles S,Raj V,Arokiaraj J,Mala K

更新日期：2017-05-01 00:00:00

abstract：:Neuroinflammation plays an important role in the progression of various neurodegenerative diseases. In this study, we investigated the anti-inflammatory effects of lonchocarpine, a natural compound isolated from Abrus precatorius, under in vitro and in vivo neuroinflammatory conditions induced by challenge with lipopo...

journal_title：Pharmacological research

authors： Jeong YH,Park JS,Kim DH,Kang JL,Kim HS

更新日期：2017-05-01 00:00:00

abstract：:An interaction of drug with food, herbs, and dietary supplements is usually the consequence of a physical, chemical or physiologic relationship between a drug and a product consumed as food, nutritional supplement or over-the-counter medicinal plant. The current educational review aims at reminding to the prescribing ...

journal_title：Pharmacological research

authors： Mouly S,Lloret-Linares C,Sellier PO,Sene D,Bergmann JF

更新日期：2017-04-01 00:00:00

abstract：:The purpose of the present work was to study the change in morphine metabolic ratio in obese subjects before and after Roux-en-Y Gastric Bypass (RYGB) and to identify clinical and/or biological factors associated with this change. The pharmacokinetics (PK) of oral morphine (30mg), morphine-3-glucuronide (M3G) and morp...

journal_title：Pharmacological research

authors： Lloret-Linares C,Luo H,Rouquette A,Labat L,Poitou C,Tordjman J,Bouillot JL,Mouly S,Scherrmann JM,Bergmann JF,Declèves X

更新日期：2017-04-01 00:00:00

abstract：:Sodium-glucose transporter 2 (SGLT2) inhibitors, also known as gliflozins, are a new class of orally active drugs used in the management of type 2 diabetes. By inhibiting the SGLT responsible for the reabsorption of glucose from the kidney, their use aims primarily to induce glycosuria and, as a consequence, lower gly...

journal_title：Pharmacological research

authors： Faillie JL

更新日期：2017-04-01 00:00:00

abstract：:Prader-Willi syndrome (PWS), the leading genetic cause of obesity, is characterized by a striking hyperphagic behavior that can lead to obesity, type-2 diabetes, cardiovascular disease and death. The molecular mechanism underlying impaired satiety in PWS is unknown. Oleoylethanolamide (OEA) is a lipid mediator involve...

journal_title：Pharmacological research

authors： Igarashi M,Narayanaswami V,Kimonis V,Galassetti PM,Oveisi F,Jung KM,Piomelli D

更新日期：2017-03-01 00:00:00

abstract：:Paradoxical sleep deprivation in rats is considered as an experimental animal model of mania endowed with face, construct, and pharmacological validity. We induced paradoxical sleep deprivation by placing rats onto a small platform surrounded by water. This procedure caused the animal to fall in the water at the onset...

journal_title：Pharmacological research

authors： Panaccione I,Iacovelli L,di Nuzzo L,Nardecchia F,Mauro G,Janiri D,De Blasi A,Sani G,Nicoletti F,Orlando R

更新日期：2017-03-01 00:00:00

abstract：:The clear importance of mutated KRAS as a therapeutic target has driven the investigation of multiple approaches to inhibit oncogenic KRAS signaling at different molecular levels. However, no KRAS-targeted therapy has reached the clinic to date, which underlies the intrinsic difficulty in developing effective, direct ...

journal_title：Pharmacological research

authors： Chuang HC,Huang PH,Kulp SK,Chen CS

更新日期：2017-03-01 00:00:00